British Prime Minister Theresa May moved significantly closer on Wednesday towards her goal of triggering Article 50 of the EU's Lisbon Treaty by the end of March and starting two years of negotiations concerning Britain's divorce from the European Union.

After three days of debate, the House of Commons overwhelmingly approved May's Brexit bill, with 494 MPs voting in favor and 122 voting against.

The prime minister told Parliament on Wednesday, "We believe it is possible within the two-year time frame to get the agreement not just for our withdrawal but also for the trade arrangements to ensure we have a strong strategic partnership in the future."

Brexit campaigner and former Conservative party leader Ian Duncan Smith said that "tonight we have started the process of delivering on ... what the people wanted."

"We've seen a historic vote tonight," Brexit minister David Davis said. "A big majority for getting on with negotiating our exit from the EU and a strong, new partnership with its member states."

The bill sailed through an earlier vote last week, with 498 MPs voting in favor and 114 against.

Almost two-thirds of British lawmakers backed the losing "Remain" side in June's historic referendum vote. However, the majority said they would vote to trigger Brexit out of respect for the voters' wishes, 52 percent of whom voted to leave the EU after four decades of membership.

One of the Brexit campaign's chief architects, former leader of the UK Independence Party Nigel Farage, expressed his delight at the vote, writing on Twitter that he never thought he would see the day the House of Commons voted in favor of leaving the EU. 

May had pledged to prioritize control of migration at the expense of membership to the EU's single market and customs union.

Pro-EU lawmakers, including members of the Scottish National Party, who on Tuesday rejected Brexit in a nonbinding vote, were reportedly whistling and singing Beethoven's Ode to Joy, the European anthem, in the chamber.

The Liberal Democrat leader, Tim Farron, who voted against the bill, vowed to fight on, saying that "in a democracy, you respect the result but you do not wave the white flag and give up."

Parliament to vote on Brexit draft agreement

Pro-EU lawmakers had tried to pass amendments to the bill that would guarantee Parliament a greater role in the divorce process. One amendment would have guaranteed tariff-free trade between Britain and the EU, while the other would have guaranteed residency rights to all EU nationals living in the UK. All amendments were defeated.

However, May appeared to bow to pro-EU MPs within her Conservative party by conceding on Tuesday that Parliament would get to have a "meaningful" vote on the "final draft agreement" for leaving the EU.

This would, in theory, give MPs and peers a say on the final withdrawal terms and any new trade deal agreed with the bloc.

However, ministers warned that if lawmakers reject the final deal, Britain would leave the EU without any agreement at all.

May said the vote on the final draft would be "before the final deal is concluded... before the European Parliament debates and votes on the final agreement." She declined to say whether it would be a "take it or leave it" vote.

House of Lords expected to seek new amendments

The Brexit bill will go to Parliament's upper chamber, the House of Lords, which has the power to delay but not derail the legislation.

May is expected to face more opposition. Lords are unelected and appointed for life, meaning that pro-EU peers will likely seek to force fresh amendments to the bill before approving it.

dm/sms (Reuters, AP)