After the emergency approval of a COVID vaccine in the UK, hundreds of people got the jab. At least two people showed allergic reactions and, as a result, people with allergies will not get the vaccine for now.
Almost the same day that it was approved, many hundreds of people got vaccinated — and two of them showed allergic reactions.
Warning for people with allergies
British authorities have described the warning as a mere safety precaution for allergy sufferers.
They say it is possible that people with allergies may experience reactions to the Pfizer-BioNTech vaccine — as was the case for two employees of the UK's National Health Service (NHS).
Both of those NHS staff members had existing allergy conditions, and both recovered soon after receiving the vaccine, said Stephen Powis, National Medical Director for NHS England, at a UK parliamentary committee hearing.
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Life-threatening reaction
People with existing allergies are being advised to be careful, however, especially if they experienced an anaphylactic shock in the past.
That's what scientists call a significant allergic reaction to food, medicines or vaccines.
Anaphylactic shock is a serious bodily reaction that can be life-threatening. It is the strongest known form of an allergic reaction and considered an absolute medical emergency.
In most cases, at least two organ systems react in the body: First, airways and the skin. Sometimes the gastro-intestinal-system reacts, and in many cases the cardiovascular system reacts.
Those sorts of reactions can come on very suddenly and a patient's condition can quickly deteriorate.
In the UK, people with allergies will not get the COVID vaccine for now.
Tell them about your allergies
There are many forms of allergic reactions, aside from the extreme, life-threatening ones. Patients can develop a skin rash, or it can become difficult for them to breathe, or the face and tongue can swell.
Authorities in the UK advise people with existing and known allergies to make that clear before they even go to get vaccinated.
Irrespective of an individual's allergy history, people with allergies will not get the vaccine for now.
That's especially the case for people who carry an adrenalin "autoinjector" pen, as was the case with the two NHS staff, who experienced a reaction.
Pfizer has told the German news agency, dpa, that the vaccine was generally well-tolerated by test participants in Phase 3 clinical trials, and that no major safety concerns were reported after an independent review of the test data.
About 44,000 people took part in the trials, and 42,000 had already received a second dose, they said.
Margaret Keenan, who was the very first person to receive the vaccine in the UK, has yet to receive her second dose.
Keenan called on everyone in the UK to take part in what has been described as the largest ever vaccination campaign — even those who are not in any of the known risk groups, such as Keenan herself, who is 90 years old.
Coronavirus rules: How much physical distancing is enough?
Physical distancing is important. But a set distance rule does not do justice to the way viruses actually spread, British researchers say. And the CDC warns: Infections can occur after only a few minutes of exposure.
Image: Reuters/M. Darlington
Keep your distance, please!
These are the coronavirus rules as we know them: Keep a distance of 1.5 to 2 meters (5 to 6 feet) from others, observe good hygiene and wear a mask. But this does not do justice to the complex reality of how aerosols spread, researchers from Oxford and London (UK) and Cambridge MA (US) have written in an analysis published in the British Medical Journal in late August.
Image: picture-alliance/dpa/J. Büttner
This much? Or more?
British Prime Minister Boris Johnson has tried to show schoolchildren how it should be done. But what does his gesture mean exactly? Do his fingertips have to be 1.5 meters away from the fingertips of another person? That would be a reasonable interpretation of the regulations. But two arm lengths alone measure 1.5 meters, so distances of 4.5 meters or more could easily result.
Image: picture-alliance/dpa/Evening Standard/L. Young
Are sheep lengths better?
The Icelandic Association of Sheep Breeders has established its own rules: Two sheep lengths are appropriate to avoid infection. One may wonder if face masks are also supposed to be knitted from real sheep's wool. This young shepherd in Senegal may be trying to find out how long a sheep is by pulling its hind leg. The Icelanders already know — exactly 1 meter.
Image: AFP/J. Wessels
Natural spacers
Of course, this could also work. The standard length of a dog leash corresponds pretty exactly to the current coronavirus rules. Could it be a coincidence that a six-foot leash is usually prescribed for places where leashes are compulsory?
Image: picture-alliance/chromorange
Where does the 2-meter rule come from?
The authors led by Lydia Bourouiba, an expert in fluid dynamics and disease transmission at MIT, writes that the rule is outdated. Two meters was the distance recommended by the German physician C. Flügge in 1897. Visible droplets that he had caught within this distance were still contagious. A 1948 study showed that 90% of streptococci coughed out in droplets flew no further than 1.7 meters.
Image: picture-alliance/dpa/PA/Jordan
Two meters are not enough
The 1948 study was published in the American Medical Journal. It also showed that 10% of streptococci flew much further: up to 2.9 meters. If that were the case, perhaps the people on this lawn on the banks of the Rhine in Dusseldorf would be safe — if every other circle remained free. But wait a minute — we are not dealing with streptococci (bacteria) here, but with viruses.
Image: picture-alliance/dpa/M. Becker
Viruses spread via aerosols
Viruses are much smaller than bacteria, so they can float around for hours and spread better in the air. This is why the researchers recommend that the distance between people should not be the only safety criterion but that other factors should be considered, too: How well a room is ventilated, whether people are wearing masks, and whether they are silent, speaking softly or singing and shouting.
Image: picture-alliance/dpa/Bayerischer Rundfunk
Do not sing or cough
Numerous studies have also shown that coughing can propel veritable parcels of viruses up to 8 meters through the air. Speaking or singing loudly also spread a lot of aerosols and droplets about the room. If, however, people only speak quietly, as in a library, and sit in the fresh air, safe distances can be smaller again.
Image: Getty Images/AFP/A. McBride
How long should I stay in the room?
The duration of a stay in a contaminated room and how many people are in that room are also decisive factors when assessing the risk of infection. The researchers have used those factors to develop a traffic light model. The clear result: In rooms with a high occupancy, you should generally stay only for a short time, make sure they are well aired, wear a mask and speak quietly.
Image: picture-alliance/dpa/S. Hoppe
One minute is enough to get infected
Even very brief contact can be enough to transmit SARS-CoV-2. The US Center for Disease Control (CDC) had to tighten its rules on October 21, after a prison guard caught SARS-CoV-2 from prisoners with whom he had only had contact with for a few minutes at a time. Now, "close contact" is defined as being within 2 metres of an infected person for at least 15 minutes cumulatively within 24 hours.
Image: picture-alliance/empics
No mask needed here
Here, however, the traffic light of the UK-US research team would show green. Outside, people can be safe for long periods of time even without a mask, provided there are few people around, everything is well ventilated and no one talks much. But even so, will the distance between deck chairs being measured here be enough?