Nirvana idol Kurt Cobain mostly played with his left hand — here on an inverted right-handed guitar. Once in a while he would pound Dave Grohl's right-handed drum kit. Cobain was a right-hander — and why he played guitar with the left is a mystery. The customized 1959 Martin D-18E guitar he played throughout the MTV Unplugged performance is being auctioned.

Although his dad tried get him to switch, Jimi Hendrix strummed his guitar with his left hand. He was able to play the other way around, though — and ate and wrote with his right hand. He famously played a right-handed Fender Stratocaster flipped over and restrung. For Left-Handers' Day, DW presents other musicians who've made it big — despite being left-handed, or precisely because of it.

Black Sabbath guitarist Tony Iommi (left) gave heavy metal its riffs. Iommi always played left-handed, which is almost a miracle: He lost his ring and middle finger tips at the age of 17 in an industrial accident. He could have switched hands, but "decided to make do with what I had, and I made some plastic fingertips for myself. I just persevered with it," he told "Guitar World" in 2008.

Sir Paul McCartney is a virtuoso on almost any instrument. He plays most of them with his left hand — including his legendary Höfner 500/1 bass. One exception: He plays a right-handed drum kit. After the Beatles dissolved in 1970, McCartney continued solo and with his band Wings.

Ringo Starr is a lefty too, but plays his drums like a righty. Any drum set can easily be rearranged for left-handed play, simply by mirroring the arrangement of all the pieces. Starr's left-handed activities limited themselves, however, to off-stage.

Phil Collins plays drums, and everything else, left-handed. That means he has the hi-hat cymbal on his right — and played with his left hand — and kicks the bass with his left foot. The musician from London became famous with progressive rock band Genesis. When he was younger, the Beatles were among his idols: He saw lefties play from early on.

Blink-182 have done a lot to boost punk rock's image. Move over Sex Pistols, here comes the pop punk of the 90s. Travis Barker is the tattooed, flamboyant drummer, and he's a southpaw. One could say he's a non-conformist through and through — except that he plays a right-handed drum set.

Elizabeth Cotten, an African-American blues singer, played in an unusual way: She simply took a right-handed guitar and turned it around — without reversing the strings. She is one of the few guitarists to have played the bass strings at the bottom with her fingers and stroke the melody with her thumb. Playing this way is therefore called "cotten picking."

Charlie Chaplin fled London's poverty early and emigrated to the States. There he reached fame with his short movies, including "The Vagabond" in 1916. In it, he plays the violin with his left hand. Privately he also played violin and cello quite well, always bowing with his left. "Every spare moment away from the studio is devoted to this instrument," read a press release from 1917.

Born in Buenos Aires, Daniel Barenboim learned piano from the masters of his day and is one of the world's most respected conductors. He is also founder of the West-Eastern Divan Orchestra, the only joint Israeli-Palestinian orchestra. Since 1992 he has been the director of the Berlin State Opera, where the left-hander picks up the baton with his right hand.