Naples' Sanità district was once associated with poverty, crime and limited opportunities. Today, local residents are helping transform the neighborhood through culture, education and grassroots initiatives. At the center of this revival are the restored Catacombs of San Gennaro, where social cooperatives train young people as tour guides and create new jobs. Once-neglected historic sites now attract visitors from around the world, generating income that supports youth development and community activities. We explore how local-led regeneration is creating new opportunities for young people, strengthening community pride and reshaping one of Naples' most challenging neighborhoods.