Mustapha Adib was only named to take over as prime minister less than a month ago. His decision to quit comes amid a deadlock over forming the next Cabinet.
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Lebanon's prime minister-designate resigned on Saturday amid a political impasse over the formation of the next Cabinet.
"I excuse myself from continuing the task of forming the government," Mustapha Adib said in a televised speech after meeting Lebanese President Michel Aoun at Baabda Palace.
The former ambassador to Germany was only named to the top job at the end of August.
Lebanon's last government stepped down in the wake of the Beirut port blast on August 4 that killed 190 people, injured thousands more and damaged many parts of the coastal capital.
The country is also struggling with a devastating economic crisis that has seen its currency lose 80% of its value since October.
Under Lebanon's sectarian political system, a Sunni must occupy the position of prime minister, while the presidency is given to a Maronite Christian and speaker of parliament to a Shiite Muslim.
In pictures: Beirut blast aftermath — destruction, chaos and protests
A powerful explosion rocked the Lebanese capital of Beirut, killing at least 150 people and injuring thousands more. Residents have taken to the streets to demand government reforms and resignations over the blast.
Image: Getty Images/D. Carde
Panic in Beirut
Two immense blasts shook Beirut and the surrounding areas of the Lebanese capital, prompting panic as residents rushed to safety. "I have never in my life seen a disaster this big," Beirut's governor told local TV.
Image: Reuters/M. Azakir
Blasts felt in city's outskirts
The explosions, centered in Beirut's port region, were felt throughout the capital. Even residents in the city's outskirts reported hearing the blast, with some saying their windows were shattered.
Image: Reuters/K. Sokhn
Dozens killed, thousands injured
Lebanon's Health Ministry said at least 100 people were killed and more than 4,000 others were injured.
Image: Reuters/M. Azakir
'Unacceptable' ammonium nitrate stock
Prime Minister Hassan Diab said that a large stockpile of 2,750 metric tons of ammonium nitrate in a warehouse at the port had caused the second, larger explosion. "It is unacceptable that a shipment of 2,750 tons of ammonium nitrate has been present for six years in a warehouse, without taking preventive measures," Diab said.
Image: Getty Images/AFP/STR
Race to save survivors
More than 30 Red Cross teams raced to the scene, with many locals lending a hand to aid rescue efforts. Hospitals warned that they were quickly filled beyond capacity — and called for blood donations as well as generators to help keep the electricity on.
Image: picture-alliance/AA/H. Shbaro
Felt as far away as Cyprus
The blasts struck with the force of a 3.5 magnitude earthquake, according to Germany's
geosciences center GFZ. Residents in Cyprus, some 110 miles (180 km) across the sea from Beirut, reported hearing and feeling the blast.
Image: Getty Images/AFP/STR
People are 'asking for their loved ones'
DW's Bassel Aridi said people were using social media to try to track down their loved ones after the explosions. Aridi also visited a hospital in Beirut after the blasts. "What I saw in the hospital was so dramatic. All the hospitals have announced that they are totally overloaded."
Image: picture-alliance/AP Photo/H. Ammar
Two-week state of emergency
Lebanese authorities fear many more people are buried beneath rubble. President Michel Aoun scheduled an emergency Cabinet meeting for Wednesday and said a two-week state of emergency should be declared.
Image: Getty Images/AFP/STR
Lebanon faces double-blow
The devastating blasts come as Lebanon experiences severe economic turbulence, with many people taking to the streets in recent months to protest the financial situation. Prime Minister Hassan Diab declared that Wednesday would be a national day of mourning for the victims of the explosion.
Image: Getty Images/D. Carde
Protesters demand reforms and resignations
Thousands of protesters took to the streets four days after the explosion, blaming the blast on government corruption and mismanagement boiling. Protesters demanded government resignations and fresh elections, with many occupying government ministries. Police responded with tear gas.
Image: Reuters/G. Tomasevic
First resignation
Information Minister Manal Abdel Samad became the first government minister to resign in the wake of the blast, five days after it took place. "After the enormous Beirut catastrophe, I announce my resignation from government," she said in a statement carried by local media. She apologized to the people of Beirut for failing them.
Image: Getty Images/AFP
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What difficulty did Adib have choosing a Cabinet?
The French-backed Abib had tried to form a Cabinet made up of independent specialists that could work on enacting reforms.
Choosing a Cabinet in this way proved difficult in a country where power is shared between Muslims and Christians and political loyalties tend to follow sectarian lines.
Assigning someone to the position of finance minister has proven particularly problematic, after the country's main Shiite groups, Hezbollah and Amal, insisted on retaining hold of the key Finance Ministry.
The two groups also named Shiite ministers in the new cabinet and objected to the manner in which Adib was forming the government.
Adib held several meetings with senior Shiite politicians but failed to reach an agreement on how the minister would be chosen. Shiite leaders feared being sidelined as Adib sought to shake up appointments to ministries, some of which have been controlled by the same faction for years, politicians said.
DW's Beirut Bureau Chief Bassel Aridi said sources had told him that they believed, until last night, that Adib would be able to form a new government.
"It seems that yesterday and this morning, there were continuous talks and calls and communications between all parties to avoid this kind of step down."
Aridi said he feared the breakdown could lead to a further collapse of the country's already-strained economic and financial situation.
Adib's resignation comes a few days after Aoun himself bluntly told reporters that Lebanon would be going to "hell" if a new government was not formed soon.