Investigators said there were "no obvious signs of trauma" or reasons to believe Prince's death was a suicide. The autopsy on the singer's body has been completed, but final results are expected to take weeks.
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Local investigators in the US state of Minnesota on Friday ruled out suicide as the cause of Prince's death.
"We have no reason to believe at this point that this was a suicide," Carver County Sheriff Jim Olson told reporters. "But again, this is early on in the investigation and we're continuing to investigate."
The sheriff added that there were "no obvious signs of trauma" on Prince's body, noting: "A sign of trauma would be some sign of violence that had happened; there was no sign of that at all." Olson did not comment on whether investigators believe foul play was involved.
Prince was found unresponsive in an elevator on the first floor at his Paisley Park compound on Thursday. Emergency crews on the scene attempted CPR but were unable to revive him and declared him dead at 10:07 local time.
Olson said the last time he was seen alive was at 8:00 p.m. on Wednesday when an acquaintance dropped him off at the compound.
A spokeswoman for the Midwest Medical Examiner's Office confirmed that an autopsy had been completed and Prince's body had been released to his family.
The spokeswoman said "it was a complete and meticulous exam" including "tissue tests" and a toxicology screen.
An official cause of death is unlikely to be announced soon, as final results from the exam will not be available for weeks.
"Gathering the results will take several days, and the results of a full toxicology scan could likely take weeks," the medical examiner's office said.
One week prior to his death, Prince was taken to a hospital with a flu-like illness, which he later downplayed.
Olsen declined to comment on reports Prince had been taking an opioid-based painkiller called Percocet.
"We are going to continue to respect his privacy and dignity," Olson said at the press conference. "We hope that you will do the same."
During a press conference in Great Britain on Friday, US President Barack Obama said "I love Prince" and called his death "a remarkable loss."
Prince: The pop legend's life in pictures
Pop genius Prince's music influenced an entire generation. His fashion sense also had a marked impact. The pop star legend, who died in 2016 at the age of 57, would have turned 65 on June 7, 2023.
Image: Nick Laham/Getty Images
Birth of a star
Prince Rogers Nelson was born in Minneapolis, Minnesota, on June 7, 1958. He had a strong interest in music early on and is said to have written his first song at the age of seven. At 20, he released his debut album, "For You." His 1979 album "Prince" went platinum due to the success of the singles "Why You Wanna Treat Me So Bad?" and "I Wanna Be Your Lover."
Image: PA/picture alliance
'Purple Rain'
His next three records, "Dirty Mind" (1980), "Controversy" (1981), and "1999" (1982), established Prince's trademark of blatantly sexual lyrics and infusion of funk, dance, and rock. In 1984, he named his backup band "The Revolution" and released "Purple Rain," which served as the soundtrack to his film debut. According to Prince, the color purple symbolized the end of the world.
Image: Ross Marino/RKA/MPI/Captital Pictures/picture alliance
Musical genius
Prince played a total of 15 musical instruments, among them guitar, drums, keyboard, electric bass and synthesizer. He often played all the instruments himself in studio productions. His global hits included songs like "Kiss" and "When Doves Cry," as well as "Purple Rain" from 1984.
Image: David Brewster/Star Tribune/Zuma/picture alliance
Debut as a director brought mixed rewards
In 1986, Prince directed and starred as a gigolo named Christopher Tracy in the musical, "Under the Cherry Moon." Despite the film's poor performance and many Golden Raspberry Awards — a parody honor highlighting the worst of cinema — the soundtrack album was critically praised as Prince's finest record yet. "Kiss" hit number one on the Billboard chart and "Mountains" reached number 23.
Image: Keystone/dpa/picture-alliance
One artist, many names
After releasing the albums "Around the World in a Day" (1985) and "Parade" (1986), The Revolution disbanded and Prince released several solo albums before debuting The New Power Generation band in 1991. He changed his stage name in 1993 to an unpronounceable symbol, which became known as the "Love Symbol." In 2000, he began referring to himself as "Prince" again.
Image: Ethan Miller/Getty Images
Love-life that both turbulent and tragic
Prince was romantically linked to many celebrities, including Kim Basinger, Madonna and Carmen Electra. In 1996, he married his 22-year-old backup singer Mayte Garcia (pictured). They had a son named Boy Gregory, who died shortly after birth from Pfeiffer syndrome — a genetic bone disorder. Two years after their divorce, Prince married Manuela Testolini. She filed for divorce in May 2006.
Image: Captital Pictures/picture alliance
Never-ending success
While his guitar may have gently wept, Prince did manage to sell over 100 million records worldwide, making him one of the best-selling artists of all time. He won seven Grammy Awards, a Golden Globe, and an Academy Award. In 2004, Prince was inducted into the Rock 'n Roll Hall of Fame. "Rolling Stone" magazine ranked Prince at number 27 on its list of the 100 Greatest Artists of All Time.
Image: Vince Bucci/Getty Images
Prince's final years
In this image, Prince is attending a match at the French Open involving Rafael Nadal in 2014. That year, Prince released a new single, "The Breakdown." He also announced that he had re-signed with his former label, Warner Bros., after an 18-year split. His penultimate album "Hit n Run Phase One" was available on the music streaming service Tidal before being released as a CD in September 2015.
Image: KENZO TRIBOUILLARD/AFP/Getty Images
A pop icon dies
His final album, "HIT 'n Run Phase Two," was first released exclusively on the Tidal streaming service on December 11, 2015. Prince was in the middle of what would be his last tour — the Piano & A Microphone Tour — when he had to postpone two performances stating that he was "battling flu." Prince was found dead at his Paisley Park complex in Minnesota on the morning of April 21, 2016.