The blast reportedly hit near an intelligence office in Damascus. Separately, Syrian officials say they repelled Israeli missiles near Damascus' airport, while Israel says it intercepted a rocket in Golan Heights.
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The Syrian capital was rocked by several major incidents on Sunday, with an explosion hitting near a military intelligence office and with Syrian state media saying forces repelled an Israeli aerial attack on Damascus International Airport.
Israel has not commented on the reports it carried out an air raid, but said that it intercepted a rocket that was fired at Syria's Israeli-occupied Golan Heights.
What we know so far:
The state-run Syrian Arab News Agency (SANA) reported that a "bomb blast" hit southern Damascus and that a "terrorist" has been arrested over the incident.
The independent war monitor Syrian Observatory for Human Rights reported that the "huge explosion" killed and wounded a number of people, although they couldn't immediately verify the death toll.
The blast, which occured during rush hour on the first day of the working week, took place near a military intelligence office and "was not a random act," the Observatory reported.
In a separate incident, SANA reported that Israel fired six missiles near Damascus International Airport, but that Syrian forces shot down five of the missiles and diverted another to empty farmland.
Israel did not directly respond to the reports, but said instead that its Iron Dome aerial defense system intercepted a rocket that was fired at the northern Golan Heights.
Syria's civil war erupted out of the Arab Spring protests that swept much of the Middle East and North Africa in 2011. The conflict has since drawn in multiple warring factions from around the world.
Image: Atta Kenare/AFP/Getty Images
War with no end
Syria has been engulfed in a devastating civil war since 2011 after Syrian President Bashar Assad lost control over large parts of the country to multiple revolutionary groups. The conflict has since drawn in foreign powers and brought misery and death to Syrians.
Image: picture alliance/abaca/A. Al-Bushy
The dictator
Syria's army, officially known as the Syrian Arab Army (SAA), is loyal to Syrian President Bashar al-Assad and is fighting to restore the president's rule over the entire country. The SAA has been fighting alongside a number of pro-Assad militias such as the National Defense Force and has cooperated with military advisors from Russia and Iran, which back Assad.
Turkey, which is also part of the US-led coalition against IS, has actively supported rebels opposed to Assad. It has a tense relationship with its American allies over US cooperation with Kurdish fighters, who Ankara says are linked to the Kurdistan Workers' Party (PKK) fighting in Turkey. Turkey has launched multiple military offensives targeting Kurdish militias.
Image: picture-alliance/AP Photo/L. Pitarakis
The eastern guardian
The Kremlin has proven to be a powerful friend to Assad. Russian air power and ground troops officially joined the fight in September 2015 after years of supplying the Syrian army. Moscow has come under fire from the international community for the high number of civilian casualties during its airstrikes. However, Russia's intervention turned the tide in war in favor of Assad.
Image: picture-alliance/dpa/Tass/M. Metzel
The western allies
A US-led coalition of more than 50 countries, including Germany, began targeting IS and other terrorist targets with airstrikes in late 2014. The anti-IS coalition has dealt major setbacks to the militant group. The US has more than a thousand special forces in the country backing the Syrian Democratic Forces.
Image: picture alliance/AP Photo/A.Brandon
The rebels
The Free Syrian Army grew out of protests against the Assad regime that eventually turned violent. Along with other non-jihadist rebel groups, it seeks the ouster of President Assad and democratic elections. After suffering a number of defeats, many of its members defected to hardline militant groups. It garnered some support from the US and Turkey, but its strength has been greatly diminished.
Image: Reuters
The resistance
Fighting between Syrian Kurds and Islamists has become its own conflict. The US-led coalition against the "Islamic State" has backed the Syrian Democratic Forces, an alliance of Kurdish and Arab militias. The Kurdish YPG militia is the main component of the SDF. The Kurds have had a tacit understanding with Assad.
Image: Getty Images/A. Sik
The new jihadists
"Islamic State" (IS) took advantage of regional chaos to capture vast swathes of territory in Iraq and Syria in 2014. Seeking to establish its own "caliphate," IS has become infamous for its fundamentalist brand of Islam and its mass atrocities. IS is on the brink of defeat after the US and Russia led separate military campaigns against the militant group.
Image: picture alliance/AP Photo
The old jihadists
IS is not the only terrorist group that has ravaged Syria. A number of jihadist militant groups are fighting in the conflict, warring against various rebel factions and the Assad regime. One of the main jihadist factions is Hay'at Tahrir al-Sham, which controls most of Idlib province and has ties with al-Qaeda.
Image: picture-alliance/AP Photo/Nusra Front on Twitter
The Persian shadow
Iran has supported Syria, its only Arab ally, for decades. Eager to maintain its ally, Tehran has provided Damascus with strategic assistance, military training and ground troops when the conflict emerged in 2011. The Iran-backed Lebanese Shiite militant group Hezbollah also supports the Assad regime, fighting alongside Iranian forces and paramilitary groups in the country.
The crackdown triggered civil strife, which has since transformed into a multi-faceted conflict that has drawn in nonstate actors, neighboring countries and global super powers, including Russia and the US.
Despite several UN-backed attempts to find a political solution to end the conflict, peace talks have floundered with no end of the war in sight.