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Trio wins Nobel Prize in medicine for immune system research

Felix Tamsut with AP, AFP, Reuters
October 6, 2025

Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi will be awarded the Nobel Prize in physiology or medicine for their instrumental work in improving our understanding of how the immune system functions.

The Nobel Assembly at Karolinska Institutet announce the Nobel Prize in Physiology or Medicine on October 6, 2025, in Stockholm, Sweden
The 11 million Swedish kronor (€1 million) prize will be split equally among the three laureatesImage: Claudio Bresciani/TT/REUTERS

The Nobel Prize in physiology or medicine for 2025 will be awarded jointly to Mary Brunkow and Fred Ramsdell of the United States and Shimun Sakaguchi of Japan for "for their discoveries concerning peripheral immune tolerance," the Nobel Assembly of Sweden's Karolinska Institute announced on Monday.

"Their discoveries have laid the foundation for a new field of research and spurred the development of new treatments, for example for cancer and autoimmune diseases," the Assembly said in a statement.

The winners will receive a prize sum of 11 million Swedish crowns (€1 million, $1.2 million), as well as a gold medal from the King of Sweden.

What is the prize's history?

The Nobel Prize in physiology or medicine has been awarded 115 times to 229 laureates between 1901 and 2024.

Last year's prize was shared by Americans Victor Ambros and Gary Ruvkun for their discovery of microRNA, which serves as on and off switches inside cells that help control what the cells do and when they do it.

The physics prize will be announced on Tuesday, with the prizes in chemistry being made public on Wednesday, and the literature one on Thursday.

Friday will see the announcement of the Nobel Peace Prize, while the Nobel Memorial Prize in economics will be announced on October 13.

The awards ceremony will be held on December 10, the anniversary of Alfred Nobel's death. Nobel was a wealthy Swedish industrialist and inventor of dynamite who died in 1896.

Nobel Prize in medicine: Why immune system research matters

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Edited by: Dmytro Hubenko

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